Boston: Printed by Wells and Lilly for Charles Ewer, December, 1820. 272p. 22cm. Text in Latin and English. First edition. Original calf. Author's presentation copy with brief inscription on the front free end paper. Bookplate on the front cover pastedown. Covers and edges worn, corners skinned, one more so; spine head flaked away; joints starting at the spine ends; text has intermittent foxing, browning and slight dampstain to top fore edge corner of some pages; one page (p. 259) torn with slight text loss; still, a very desirable copy of this rare work, the first official Pharmacopoeia of the United States. [Sabin 61351].